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For use in healthy cattle and sheep as an aid in preventing blackleg caused by Clostridium chauvoei, malignant edema caused by Cl septicum, black disease caused by Cl. novyi, gas-gangrene caused by Cl. sordellii, and enterotoxemia and enteritis caused by Cl. perfringens types B, C, and D. Although Cl. perfringens type B is not a significant problem in North America, immunity is provided by the beta toxoid of type C and the epsilon toxoid of type D.